What is Bioactivity?

Posted on February 1st, 2023

People who are interested in buying and using cannabidiol might have questions, with one of them being is CBD a bioactive compound? They might also wonder, what does bioactivity mean, and hope to explore the key differences between bioavailability and bioactivity. Before anyone purchases CBD products, they’ll want to read the rest of this article to find out the answers to those questions.

What Does Bioactivity Mean

So, what does bioactivity mean? In short, bioactivity refers to specific effects that kick in once you’re exposed to a certain substance. For example, if you take CBD + CBDA that’s supposed to calm you down? Well, once you feel calm, you’ve experienced bioactivity.

Now, that’s just one small example. But as for what other effects might occur, that depends on the substance you take. Some bioactive substances produce effects such as increased metabolism or tissue uptake. In some cases, bioactivity can also produce a physiological response.

It’s important to note that bioactivity also refers to a substance’s adverse effects on living matter, such as tissue within the body. Furthermore, bioactivity usually depends on dosage. For example, you might need to take high doses in order to produce the expected bioactive effect.

Also, effective compounds must have a specific target. (For example, muscle tissue.) However, those compounds also need the right ADME balance. (That’s short for absorption, distribution, metabolism and excretion.) If a substance doesn’t contain the right balance of ADME, then it probably won’t live up to its bioactive potential.

Is CBD A Bioactive Compound

The short answer is yes, cannabidiol is a bioactive compound. It’s one of the main active compounds in cannabis plants, alongside over a hundred others such as THC (tetrahydrocannabinol) CBC (cannabichromene), CBN (cannabinol) and more. To be more specific, cannabidiol and these other compounds are phytocannabinoids. And that term refers to any bioactive compounds that we can extract from cannabis plants.

It’s important to note that both CBD and THC are bioactive compounds. However, both compounds interact with your body differently. And what is one of those key differences? THC influences how your brain works, and can get you “high”. CBD is non-psychoactive, which means it does not produce a “high”.

Bioavailability vs Bioactivity: What’s The Difference

Many people confuse bioavailability with bioactivity. Although the two share similarities, they are completely different things. Read on to learn more about bioavailability and bioactivity.

  1. Bioavailability-

This refers to the amount of a substance your body absorbs and uses. For example, when you take CBD, you want your product to have high bioavailability. Higher availability means your body will absorb more CBD and use it according. In turn, you will have a better chance of experiencing effects from your cannabidiol.

Let’s say a person buys a CBD product that only has low bioavailability, such as a gummy or other edible. After taking and digesting the edible product, only a small amount of CBD will likely enter the bloodstream. In turn, the person probably won’t notice many effects from the product with low bioavailability.

  1. Bioactivity-

Bioactivity is the effect that a substance causes. Once you’re exposed to CBD, you may experience a number of effects. Once you feel them? That’s when bioactivity has taken or is taking place.

In short, bioactivity doesn’t refer to the amount of a substance circulating within the body. Instead, it is all about the effects a particular substance produces once a person is exposed to that substance. In this case, that substance would be cannabidiol.

CBD’s Bioactivity & Bioavailability

It’s important to use CBD products with high bioavailability and bioactivity. This will help you experience more effects from your daily supplement. Certain forms of CBD come with higher bioavailability, while others will be less useful in your body.

To help you understand how to calculate the bioavailability of a product, here’s a brief glimpse at the science behind this concept. Basically, four factors determine bioavailability. These include:

  • Absorption.

Cannabinoids are lipophilic molecules; hence, they are not soluble in water and tend to float. The human body is mostly made of water; hence cannabinoids generally have low bioavailability as they are not as easily absorbed. This is why it is crucial to choose a product with high bioavailability.

  • Distribution.

When it comes to distributing cannabinoids to several parts of the body, transdermal, intranasal, and transmucosal methods are better than oral methods. CBD easily disperses into the bodily tissues and organs where it may relieve the symptoms you are experiencing.

  • Metabolism.

Metabolism also greatly affects bioavailability. This is how molecules break down in the body, and it can hinder absorption. For example, the liver metabolizes CBD when taken orally; hence this affects its bioavailability greatly.

  • Excretion.

CBD metabolites are mostly excreted through the kidney. Here is where products with high bioavailability are encouraged. They will be absorbed and distributed to other organs and parts of the body instead of being cleared immediately.

Now, if all that science is a bit too much for you? No worries, here’s a breakdown on the CBD delivery methods that produce the lowest and highest degrees of bioavailability.

CBD topicals have low bioavailability, as no matter how much of a product you apply to your skin, very little will able to reach the bloodstream. Edible forms of CBD also come with low bioavailability, since they have to pass through your digestive tract before they hit your blood. Now, tinctures have higher bioavailability. And vapes produce some of the highest bioavailability levels, but also come with serious health risks, especially for your lungs.

What about bioactivity? If a specific CBD product has high bioactivity, then you will feel its potential effects sooner rather than later. On top of that, a product with high bioavailability contains cannabidiol that your body can absorb efficiently. And that means that a good amount of it will circulate within your body.

What is Bioactivity? Conclusion

There are clear differences between bioavailability and bioactivity. Both are important, especially when it comes to CBD products.

That is the answer to the question: What does bioactivity mean? CBD is a bioactive compound. But not all CBD products are created equal. To get the most from your cannabidiol experience, purchase products from a reputable company that sells high-quality, lab-tested CBD products. Or, get 2X more noticeable effects from your product by purchasing hemp-extracts from Tanasi: they all contain a patent-pending blend of CBD+CBDA!


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